Lineup Rx · Week 10 · 2026
Thirteen games are left this week: 12 on Sunday, starting with Patriots-Lions in Munich at 6:30 AM PT, and Chargers at Ravens on Monday night. Chicago, Denver, Philadelphia and Tampa Bay are on bye, and Washington beat the Giants 24-21 on Thursday, per the CBS Sports schedule. Every call is for 12-team half-PPR leagues, with a note where full PPR changes the answer. Kickoffs are in Pacific time, with Eastern in parentheses.
Lines come from VegasInsider and Sportsbook Review’s bet365 numbers. Where the two books disagree, I show the range. Injury designations come from Friday’s final team reports and NFL.com’s Week 10 injury page, plus Saturday news where a row says so. The calls lean on those reports, NFL.com’s four Week 10 start/sit columns and FantasyPros’ Week 10 grades. When a status rests on one outlet, I say so.
Trades reshuffled three starting quarterbacks and two receivers. Kirk Cousins starts for Minnesota five days after the trade from Las Vegas, Fernando Mendoza makes his first start for the Raiders, and Jacoby Brissett is in line to start Monday for Baltimore with Lamar Jackson on injured reserve. Indianapolis sent Keenan Allen to San Francisco and Josh Downs to Kansas City.
Our Friday Rounds has the full practice-report breakdown. Pickups are in Free Agent Triage, trade targets are in Trade Rx, and the Puka Nacua knee is in Recovery Room. One change since Friday Rounds: Kenneth Walker III is out, covered below.
This week’s prescriptions
NFL.com’s start of the week. He has scored double-digit points in every game, and New Orleans allows the second-highest rush success rate to backs (44.1%).
Jeanty has rushed for fewer than 30 yards in five straight games, and Seattle allows the fourth-fewest rushing yards per game.
Detroit allows 25.1 fantasy points per game to tight ends, nearly double the league average. Henry is off the injury report.
Kenneth Walker III was downgraded to out with a groin strain. Johnson leads the backfield at Atlanta for the first time.
Injury watch
| Player | Status | What to do |
|---|---|---|
| Kenneth Walker III, KC | Out (groin) | Downgraded Saturday, also reported by Yahoo Sports. Start Emmett Johnson as an RB2. Jaydn Ott (hamstring) is questionable. |
| A.J. Brown, NE | Questionable (ankle/knee) | Limited all week and tracking toward a return. Start him if active. Inactives post at 5:00 AM PT. |
| Rhamondre Stevenson, NE | Questionable (knee) | DNP, limited, limited. Start him if active and Corey Kiner if not. TreVeyon Henderson (illness) is out. |
| Amon-Ra St. Brown, DET | Questionable (rib) | Limited all week for a second straight week. Start him. |
| Kyler Murray, T.J. Hockenson, Jauan Jennings, MIN | Out (hamstring, wrist/chest, calf) | Kirk Cousins starts. Jordan Addison (thumb) is questionable after a limited Friday. |
| Josh Jacobs, GB | Out (finger) | Kaleb Johnson is the likely lead back. Chris Brooks (ankle) is questionable. |
| Garrett Wilson, NYJ | Questionable (concussion) | Limited, limited, full. Aaron Glenn is confident he plays. Start him. |
| Marvin Harrison Jr., HOU | Out (hamstring) | Tank Dell is the receiver most likely to pick up targets. |
| David Montgomery, HOU | Questionable (groin) | DNP, limited, full. RotoWire reported Saturday that he was downgraded to out. I could not confirm that with a second source, so sit him either way and start Woody Marks. |
| Travis Etienne Jr., NO | Questionable (hamstring) | Limited, limited, full, but he still has to come off injured reserve. Sit him. CJ Donaldson is out. |
| Jonathon Brooks, CAR | Out (groin) | Downgraded from doubtful Saturday, also reported by RotoWire. Chuba Hubbard carries the backfield. |
| Chris Bell, MIA | Doubtful (knee) | Kyle McCord starts with Malik Willis on injured reserve. Caleb Douglas is a PPR flex. |
| Carnell Tate, TEN | Out (shoulder) | Three straight DNPs. Tyjae Spears is questionable after a full practice. |
| Puka Nacua, Davante Adams, Terrance Ferguson, LAR | Out (knee/toe, hamstring, ankle/hamstring) | Tyler Higbee is the tight end streamer. Downgrade Matthew Stafford. |
| Sam Darnold, SEA | Out (ribs/quad) | Drew Lock starts again. Jaxon Smith-Njigba is still a start. |
| Mike Evans, SF | Out (Achilles) | Deebo Samuel has no designation and returns for the first time since Week 5. Keenan Allen debuts for the 49ers. |
| Jake Ferguson, Tyler Goodson, DAL | Out (knee/ankle) | George Pickens is not on the Cowboys’ final report and is expected to return. Start him. |
| Andrei Iosivas, CIN | Out (thumb) | Doubtful on Friday’s report, then kept on injured reserve Saturday, per RotoWire. No fantasy change for Chase or Higgins. |
| Zachariah Branch, ATL | Out (hamstring) | Drake London’s target share holds. |
| Ladd McConkey, LAC | DNP Thursday and Friday (back) | Game statuses for Monday night were not posted when this went up. Brenen Thompson (hamstring) also missed both days, and David Njoku (fibula) was limited. Bench McConkey. |
Patriots vs. Lions (Munich)
The diagnosis: This game decides a lot of lineups before most people wake up. Detroit allows 25.1 fantasy points per game to tight ends, and Henry’s 86.5% catch rate is the best among non-running backs with 30 or more targets, which is why NFL.com made him its tight end start of the week. FantasyPros ranks Jahmyr Gibbs first among running backs, Drake Maye third among quarterbacks and St. Brown fourth among receivers. Sam LaPorta is the Lions’ weak spot. New England allows the seventh-fewest points to tight ends, and he has been under eight points in each of his last three games. A.J. Brown and Stevenson are questionable after limited practices, so set a backup before Saturday night ends.
- StartJahmyr Gibbs, Drake Maye, Jared Goff, Amon-Ra St. Brown, Jameson Williams, Hunter Henry, A.J. Brown (if active)
- BorderlineRhamondre Stevenson (if active; Corey Kiner if not), DeMario Douglas (start him if Brown sits), Sam LaPorta (low-end TE1), Eli Raridon (deep leagues)
- SitSione Vaki, Cameron Latu (both questionable), both D/STs
Vikings at Packers
The diagnosis: Kevin O’Connell named Cousins the starter on Friday, less than a week after the trade, and ESPN confirms it. He replaces Carson Wentz, who went 8 of 25 for 81 yards against Buffalo. Cousins loses Hockenson and Jennings, and Addison is questionable, so Justin Jefferson should see a heavy target load. On the Green Bay side, NFL.com still starts Jordan Love because he is the only quarterback to finish as a QB1 against Minnesota this season. Tucker Kraft is NFL.com’s tight end sit of the week. Minnesota allows 3.9 catches and 9.3 fantasy points per game to tight ends, both league lows. With Jacobs out, Kaleb Johnson should get most of the carries, but FantasyPros leaves him out of its top 30 backs.
- StartJustin Jefferson, Jordan Love, Christian Watson, Matthew Golden, Packers D/ST
- BorderlineKaleb Johnson (RB2/flex on volume), Jordan Addison (flex, only if active)
- SitKirk Cousins, Tucker Kraft, Jordan Mason, Aaron Jones, Chris Brooks
Chiefs at Falcons
The diagnosis: Walker leads the league with 109.0 rushing yards per game, and Kansas City is holding him out as a precaution. Emmett Johnson takes over, with 111 rushing yards at 4.3 per carry and 14 catches for 237 yards this season. Jaydn Ott and Nate Carter will mix in. Treat him as a volume play with a short track record. NFL.com says Patrick Mahomes could throw more without Walker, and Josh Downs should see extra targets in his first game as a Chief. Bijan Robinson and Drake London are FantasyPros’ RB5 and WR15. Kyle Pitts is down at TE15.
- StartPatrick Mahomes, Rashee Rice, Bijan Robinson, Drake London
- BorderlineEmmett Johnson (RB2 on volume), Travis Kelce (FantasyPros TE7), Josh Downs (PPR flex), Chiefs D/ST
- SitKyle Pitts, Xavier Worthy, Jaydn Ott, Falcons D/ST
Bills at Jets
The diagnosis: Josh Allen is FantasyPros’ top quarterback and James Cook is its RB4. Dalton Kincaid went limited, limited, full and carries no designation, per the joint report. On the Jets side, Garrett Wilson should clear the last step of the concussion protocol. Omar Cooper Jr. is questionable but practiced fully Friday, and NFL.com likes him as the top target outside Wilson. Breece Hall out-carried Braelon Allen 15 to 8 in his first game back, per NFL.com, but a 7.5-point spread could leave New York throwing late.
- StartJosh Allen, James Cook, DJ Moore, Garrett Wilson
- BorderlineBreece Hall (RB2), Dalton Kincaid (TE1 range), Omar Cooper Jr. (PPR flex), Khalil Shakir (PPR flex)
- SitBraelon Allen, Adonai Mitchell (questionable), Jets QB, Jets D/ST
Jaguars at Titans
The diagnosis: This is the biggest spread on the board. Bhayshul Tuten is off Jacksonville’s final report, per NBC Sports, and FantasyPros ranks him RB11, with Trevor Lawrence at QB5 and Parker Washington at WR9. Tennessee is without Carnell Tate. NFL.com sits Tony Pollard because he scored five touchdowns in two games after one in the first six, and Jacksonville allows the second-fewest rushing yards per game. It also sits Brenton Strange, whose volume has dropped as the Jaguars run up scores.
- StartTrevor Lawrence, Bhayshul Tuten, Parker Washington, Jaguars D/ST
- BorderlineJakobi Meyers (WR3), Chris Rodriguez Jr. (flex)
- SitTony Pollard, Brenton Strange, Tyjae Spears, Chimere Dike (deep leagues only), Titans D/ST
Texans at Browns
The diagnosis: C.J. Stroud is NFL.com’s quarterback start of the week. He scored 35.36 points in Week 9 and averages 23.78 over his last five games, and since Week 4 he ranks in the top three in passer rating, success rate and EPA per dropback. Without Harrison, more targets go to Nico Collins and Tank Dell. Houston’s D/ST is FantasyPros’ top unit. Deshaun Watson is expected to start for Cleveland after clearing the concussion protocol, per Yahoo’s tracker. Quinshon Judkins posted a season-low 5.5 points against New Orleans last week, and NFL.com no longer trusts him as an RB2.
- StartC.J. Stroud, Woody Marks, Nico Collins, Texans D/ST
- BorderlineTank Dell (flex), Quinshon Judkins (flex), Harold Fannin Jr. (TE2)
- SitDeshaun Watson, David Montgomery (likely out), Denzel Boston (questionable, toe), Browns D/ST
Panthers at Saints
The diagnosis: Hubbard ranks sixth among running backs in fantasy points per game, and New Orleans also allows the third-most yards after contact per carry (3.7). Jonathon Brooks was downgraded to out on Saturday, so the work is all his. Bryce Young scored 20.34 points against Denver last week, and NFL.com says New Orleans gave up 22.68 to Shedeur Sanders. Jalen Coker is a riskier start after three single-digit games, but the Saints allow the second-most receiving yards per game on deep targets. Etienne would be coming straight off injured reserve, so stay away. Devaughn Vele ran far fewer routes than Jordyn Tyson last week.
- StartChuba Hubbard, Tetairoa McMillan, Chris Olave, Jalen Coker
- BorderlineBryce Young (streamer; FantasyPros QB13), Tyler Shough (QB2 range; QB9), Jordyn Tyson (deep flex), Saints D/ST
- SitTravis Etienne Jr., Alvin Kamara, Audric Estime, Devaughn Vele, Darren Waller, Xavier Legette (questionable)
Dolphins at Colts
The diagnosis: This total is tied for the lowest of the week. Kyle McCord makes his first NFL start for Miami, and Indianapolis traded away Keenan Allen and Josh Downs before the deadline, so both passing games are thin. Lean on the running backs. Ollie Gordon II had 16 carries against Detroit, and the Colts allow the third-most yards per carry to running backs (4.8). FantasyPros ranks Jonathan Taylor RB12, Gordon RB13 and Tyler Warren TE5. With Chris Bell doubtful, Caleb Douglas gets more targets, but those targets come from a first-time starter.
- StartJonathan Taylor, Ollie Gordon II, Tyler Warren
- BorderlineCaleb Douglas (PPR flex), Colts D/ST
- SitKyle McCord, Daniel Jones, Chris Bell, Dolphins D/ST
Rams at Cardinals
The diagnosis: Matthew Stafford is NFL.com’s quarterback sit of the week. He has not finished higher than QB12 in any week without Davante Adams, and Nacua and Adams account for about half of his yards and touchdowns. Both are out, which leaves Tutu Atwell and Konata Mumpfield. A 9.5-point spread points to the run game. Blake Corum has scored double-digit points with a touchdown in five straight weeks, and FantasyPros has Kyren Williams at RB10. Arizona starts rookie Carson Beck with Gardner Minshew on injured reserve, per The Fantasy Footballers. Trey McBride is still FantasyPros’ TE3.
- StartKyren Williams, Blake Corum, Trey McBride, Rams D/ST
- BorderlineTyler Higbee (TE streamer)
- SitMatthew Stafford, Carson Beck, Tutu Atwell, Konata Mumpfield, Cardinals D/ST
Seahawks at Raiders
The diagnosis: Mendoza, the No. 1 overall pick, makes his first start against a defense that allows the second-fewest fantasy points per game to quarterbacks (10.44). Seattle also allows the fewest receiving yards per game to receivers (99.6), which sinks Tre Tucker. Jeanty needs about six catches or a touchdown to reach RB2 range, per NFL.com. Brock Bowers is the only Raider to start. Drew Lock starts again for Seattle, and Jaxon Smith-Njigba is FantasyPros’ top receiver. Zach Charbonnet (RB16) is ahead of Jadarian Price (RB23).
- StartJaxon Smith-Njigba, Brock Bowers, Seahawks D/ST
- BorderlineZach Charbonnet (RB2/flex), Jadarian Price (flex)
- SitAshton Jeanty, Fernando Mendoza, Drew Lock, Tre Tucker, Raiders D/ST
49ers at Cowboys
The diagnosis: This is the highest total of the week, 4.5 points above the next game. Dak Prescott has finished as a QB1 in three straight games with 19 or more points, and he has 15 touchdowns and four interceptions from a clean pocket against a 49ers defense that has not pressured anyone. Pickens is off the Cowboys’ final report. San Francisco gets Deebo Samuel back with no designation and adds Allen, who had 40 catches for 351 yards in eight games with Indianapolis. Evans is out. FantasyPros ranks Brock Purdy QB2, Christian McCaffrey RB3 and George Kittle TE1. With Ferguson out, Dallas has no tight end worth starting.
- StartBrock Purdy, Christian McCaffrey, George Kittle, Dak Prescott, CeeDee Lamb, Javonte Williams, George Pickens
- BorderlineKeenan Allen (PPR flex), Deebo Samuel (flex in his first game back), Ryan Flournoy (deep flex)
- SitMike Evans (out), Dallas tight ends, both D/STs
Steelers at Bengals (Sunday Night Football)
The diagnosis: Joe Burrow, Ja’Marr Chase and Tee Higgins are all near the top of FantasyPros’ rankings, and Jaylen Warren is its RB7 against a Bengals run defense 4for4 rates bottom six in efficiency. DK Metcalf is NFL.com’s receiver sit of the week. He has two games with 60 or more yards all season and caught three passes for 31 yards against Cincinnati in Week 3. Pat Freiermuth is a fair streamer, since Cincinnati allows the second-most receiving yards per game to tight ends. This is the last game of the day, so you get no pivot if a Sunday night player sits.
- StartJoe Burrow, Ja’Marr Chase, Tee Higgins, Jaylen Warren
- BorderlineChase Brown (RB2), Pat Freiermuth (TE streamer), Germie Bernard (WR3)
- SitDK Metcalf, Aaron Rodgers, Rico Dowdle, Andrei Iosivas (out), both D/STs
Chargers at Ravens (Monday Night Football)
The diagnosis: Zay Flowers is NFL.com’s receiver start of the week. He scored 5.3 points over the last two weeks with Joe Fagnano mostly at quarterback, but before that he was WR5 in points per game and second in yards per route run (3.7). Brissett takes over Monday, and the 0-8 Chargers allow the fifth-most points per game to receivers. Derrick Henry is FantasyPros’ RB8, and the Ravens D/ST ranks fourth. NFL.com sits Omarion Hampton, who has scored fewer than eight points in four straight games, and Mark Andrews, who has not reached 30 receiving yards since Week 2. McConkey missed Thursday and Friday with back spasms. The Chargers had not posted Monday game statuses when this went up, so check their Saturday report before you start anyone from Los Angeles.
- StartZay Flowers, Derrick Henry, Ravens D/ST
- BorderlineRashod Bateman (deep flex; full Friday after a calf injury)
- SitJustin Herbert, Jacoby Brissett, Omarion Hampton, Ladd McConkey, Mark Andrews, David Njoku, Chargers D/ST
Before you lock your lineup: Inactives come out 90 minutes before each kickoff. That’s 5:00 AM PT (8:00 AM ET) for Munich, 8:30 AM PT (11:30 AM ET) for the 1:00 PM ET games, 11:35 AM PT (2:35 PM ET) for the 4:05 PM ET games, 11:55 AM PT (2:55 PM ET) for 49ers-Cowboys, 3:50 PM PT (6:50 PM ET) for Sunday night and 3:45 PM PT (6:45 PM ET) for Monday night. If you’re starting A.J. Brown, Stevenson or St. Brown, put a backup from a later game in your flex so you can still swap.
About Lineup Rx: FFD posts start/sit calls for every Sunday and Monday game each Saturday at noon Pacific, after the final Friday injury designations. For live statuses, check the FFD Injury Report.
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